Clascoterone属于局部雄激素受体抑制剂,能够直接在头皮局部阻断二氢睾酮(DHT)与雄激素受体的结合,同时全身吸收量极低,从根源上降低了系统性不良反应的风险。临床试验数据显示,其治疗相关不良事件发生率与安慰剂相当,未出现系统性雄激素抑制相关不良反应。这意味着,Clascoterone有望同时实现脱发治疗的安全性与高效性,为那些因恐惧性功能障碍等副作用而对口服非那雄胺望而却步的庞大患者群体,提供首个真正意义上的替代选择。
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While it’s true that each oil crisis was accompanied by inflation in some countries, that doesn’t mean that a surge in oil prices caused their inflations. In the U.S., the inflations of 1973-75 and 1979-81 were generated by prior surges in broad money, as measured by the growth of M2, the term economists use for the “money supply” in the economy, during the two to three years preceding the outbreak of each inflationary episode. (Briefly, M2 is all the bills and coins in circulation as well as checking accounts, plus less liquid investments such as savings accounts and certificates of deposit.)
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