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In the human genome, homopolymers tend to occur more often in adenine and thymine runs than guanine and cytosine. There are are approximately twice as many nucleotides within A or T homopolymers (481 Mb and 484 Mb) than G or C (278 Mb and 279 Mb). This discrepancy is even more pronounced when looking at homopolymers longer than four nucleotides (c.f. Figure 1.5).
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