This time, Kaley did agree that her mother was being physically and emotionally abusive during the time that she was self-harming around when she was in the 6th grade. She testified earlier in the day that she doesn’t think she would label her mother’s past actions as abuse or neglect today.
作者发现了一条从吻侧前扣带皮层锥体神经元(rACCPy)到中脑导水管周围灰质GABA能神经元(PAGGABA)的兴奋性下行神经环路,在瘙痒抑制中发挥关键作用。在瘙痒诱发抓挠行为期间,被标记为“瘙痒相关”的rACCPych神经元活动显著降低。人为激活该神经环路会显著削弱瘙痒反应,而抑制该环路则会增强瘙痒反应。因此,作者鉴定出一条兴奋性神经环路在瘙痒的下行调控中起着至关重要的抑制作用,提示该环路可能成为治疗瘙痒的潜在靶点。
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